Genetically engineered pig models of neurological diseases

Genetically modified animal models are commonly used for in vivo studies of human diseases. Mice the most common biomedical research, which have provided important insights into disease pathogenesis and widely to find treatments However, due differences anatomical structure physiological function between mouse brains, genetically cannot fully recapitulate overt selective neuronal loss seen age-dependent neurodegeneration While non-human primates (NHP) closer humans been model disease, these difficult be utilized at a large scale various limitations including their high costs, prolonged breeding time, community concerns use NHP, ethical standards. As an resource agriculture, pigs also as research. The central nervous system is highly similar that humans, making pig suitable investigating neurological relatively short period, litter size, established somatic cell transfer technology advantages over NHP using recent development gene editing tools allows one more efficiently generate can precisely mimic genetic mutations In this review, we summarize advances modeling diseases, new approaches generating models.